Conference Schedule for Day 1
Monday, June 22
Track: Skin/Sun Science
Nature-Inspired Design of New Biodegradable Pseudo-Protein Biomaterials as Potential for Cosmetic and Human Body Repair
Speaker: Chih-Chang (C.C.) Chu, PhD, Rebecca Q. Morgan '60 Professor, Fiber Science Program, Dept. of Textiles and Apparel; Biomedical Engineering Program, Cornell University
Monday, June 22 12:05–12:35pm
This lecture will describe how wonderful and extricable natural objects and their structures can inspire scientists/engineers to design their own "human spare parts" for human body repair, including potential cosmetic applications. The concept of "composite" architecture at the macroscopic level from nature will be elucidated, which inspired Chu for his design of a totally new family of biodegradable pseudo-protein biomaterials at the molecular level by integrating biology, chemistry, material science/engineering, pharmacy and medicine.
Chu’s talk will focus on a new family of novel biodegradable materials, amino acid-based poly(ester amide)s (AA-PEAs), synthesized from from three building blocks: amino acids, fatty diacids and fatty dialcohols. As a result, the backbone chemical structure of AA-PEAs has both peptide and non-peptide bonds, and hence exhibit both protein and non-protein properties; thus, the nickname “pseudo-proteins.” Due to the enormous variety and availability of these three building blocks, a wide range of AA-PEAs could be tailor-designed for meeting specific clinical and cosmetic needs. Some members of this AA-PEA family are water-soluble, while other members are not. Some will have charges, while others do not.
These new AA-PEA polymers have been engineered in a wide range of physical forms ranging from 3D microporous hydrogels, fibers, electrospun fibrous membranes, films, micro- and nanospheres, and micelles. All of these have shown several unique biological properties, including: supporting cell growth, facilitating natural wound healing, and muting foreign-body induced inflammatory response. Further, Chu's research group at Cornell has also discovered this new family of AA-PEAs can overcome the shortcomings of commercially available FDA-approved materials for human body repair—particularly foreign-body induced inflammatory response.
Besides the general characteristics of this new family of pseudo-protein biomaterials, in his talk, Chu will focus on a particularly new member of AA-PEA designed from peptide-based PEA that is expected to have the potential in cosmetic industry. This new tripeptide-based PEA is designed from the well-established role of peptides in cosmetic use, particularly the GHK peptide (Gly-His-Lys). The advantage of GHK-based PEA over GHK is that the GHK-based PEA is in polymer form, and hence can be formulated into a wide range of physical forms like micro/nanoparticles, fibrous membranes, hydrogels, etc., which GHK cannot. In addition, GHK-based PEA can provide a much higher concentration of GHK tripeptide, as a single GHK-based PEA could have hundreds to thousands of GHK. This versatility could allow cosmetic scientists to formulate GHK-based PEA for their particular needs.
Some unique biomedical applications of these AA-PEA materials ranging from heart stent and suture coatings, vascular patches, drug delivery vehicles and burn dressings, to non-viral gene delivery will be briefly described.
Track: Joint Session
Translating Sensation to (and from) Personal Care
Speaker: John Hayes, PhD, Professor, Sensory Science, and Director, Sensory Evaluation Center, Pennsylvania State University
Monday, June 22 2:00–2:30pm
Details forthcoming. According to market research, converging multiple sensory experiences in one personal care product can help it stand out on shelves. Touch and sight are standard, but sound and smell also are becoming players. In this presentation, Dr. Hayes will provide insight on sensorial triggers to stir creative new ideas for cosmetics R&D to develop products that "speak" to consumers and stand out from the competition.
Track: Joint Session
Environmentally Benign Nanoparticles for Improved Preservation
Speaker: Alexander Richter, PhD Candidate, Velev Group, Dept. of Chemical and Biomolecular Engineering, North Carolina State University
Monday, June 22 2:35–3:05pm
Details forthcoming. This presentation will describe the design and fabrication of functionalized nanoparticles with improved efficacies for various applications; preservation will specifically be described. These lignin and cellulose-based environmentally benign nanoparticles (EbNPs) deliver higher efficiency, in terms of active agent employed, in comparison with persistent nanoparticle systems. For example, silver ion-infused EbNPs with a positive surface charge (Ag-EbNP-PDADMAC) exhibit significantly higher antimicrobial activity, in terms of Ag equivalent, than other silver nanoparticles against the human pathogens E. coli and P. aeruginosa. These particles also may be employed for improved emulsion stability and delivery efficacy, which will be touched upon.
All exhibitors, sessions, presenters, times and locations are subject to change without notice.